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Showing 51–100 of 112 results

Advanced filters: Author: James F Mead Clear advanced filters

Multiparameter prediction of myeloid neoplasia risk

An analysis of UK Biobank participants shows that the risk of developing different types of myeloid neoplasms can be inferred years before diagnosis. The authors integrate somatic gene mutations with blood test parameters into a predictive model, which could guide future strategies for early detection and prevention of these diseases.

Muxin Gu
Sruthi Cheloor Kovilakam
George S. Vassiliou
ResearchOpen Access24 Aug 2023
Nature Genetics

Volume: 55, P: 1523-1530
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Somatic mutations drive the clonal proliferation of myeloproliferative neoplasms. Here the authors conduct a genome-wide association study and identify germline variation at multiple loci associated with the development and disease phenotype of these cancers.

William Tapper
Amy V. Jones
Nicholas C.P. Cross
ResearchOpen Access07 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants.

Michael Rusch
Joy Nakitandwe
Jinghui Zhang
ResearchOpen Access27 Sept 2018
Nature Communications

Volume: 9, P: 1-13
Warning signals of biodiversity collapse across gradients of tropical forest loss

Fabio de Oliveira Roque
Jorge F. S. Menezes
William F. Laurance
ResearchOpen Access26 Jan 2018
Scientific Reports

Volume: 8, P: 1-7
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Quantifying the impact of Wolbachia releases on dengue infection in Townsville, Australia

Samson T. Ogunlade
Adeshina I. Adekunle
Emma S. McBryde
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Microfluidics with fluid walls

The complexity of fabricating and operating microfluidic devices limits their use. Walsh et al. describe a method in which circuits are printed as quickly and simply as writing with a pen, and liquids in them are confined by fluid instead of solid walls.

Edmond J. Walsh
Alexander Feuerborn
Peter R. Cook
ResearchOpen Access10 Oct 2017
Nature Communications

Volume: 8, P: 1-9
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.

Claire Vennin
Pauline Mélénec
Paul Timpson
ResearchOpen Access12 Aug 2019
Nature Communications

Volume: 10, P: 1-22
Climate and landscape drivers of a mosquito-borne pathogen in an iconic game bird in the eastern and upper midwestern USA

Melanie R. Kunkel
James A. Martin
Nicole M. Nemeth
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
New-onset IgG autoantibodies in hospitalized patients with COVID-19

Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.

Sarah Esther Chang
Allan Feng
Paul J. Utz
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Author Correction: Female sex mitigates motor and behavioural phenotypes in TDP-43^Q331K knock-in mice

Jodie Watkins
Anshua Ghosh
Jemeen Sreedharan
Amendments and CorrectionsOpen Access20 May 2021
Scientific Reports

Volume: 11, P: 1
Age- and Dietary-Related Distributions of Hepatic Arachidonic and Docosahexaenoic Acid in Early Infancy

James Farquharson
E Cherry Jamieson
Forrester Cockburn
Research01 Sept 1995
Pediatric Research

Volume: 38, P: 361-365
Vascular Endothelial Growth Factor-A Induces Prenatal Neovascularization and Alters Bronchial Development in Mice

Ann L Akeson
James E Cameron
James M Greenberg
Research01 Jan 2005
Pediatric Research

Volume: 57, P: 82-88
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

Mark H Tuszynski
Leon Thal
James Conner
Research24 Apr 2005
Nature Medicine

Volume: 11, P: 551-555
SciPy 1.0: fundamental algorithms for scientific computing in Python

This Perspective describes the development and capabilities of SciPy 1.0, an open source scientific computing library for the Python programming language.

Pauli Virtanen
Ralf Gommers
Yoshiki Vázquez-Baeza
ReviewsOpen Access03 Feb 2020
Nature Methods

Volume: 17, P: 261-272
Ground water and climate change

Groundwater is of crucial importance for water and food security and for sustaining ecosystems. This Review assesses the likely impacts of climate change on groundwater and groundwater-driven feedbacks to the climate system.

Richard G. Taylor
Bridget Scanlon
Holger Treidel
Reviews25 Nov 2012
Nature Climate Change

Volume: 3, P: 322-329
Extensive phenotypic characterisation of a human TDP-43^Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS)

Jodie A. Watkins
James J. P. Alix
Richard J. Mead
ResearchOpen Access17 Aug 2021
Scientific Reports

Volume: 11, P: 1-14
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Julie Williams and colleagues report a genome-wide association study for Alzheimer's disease. They identify variants at the CLU and PICALM loci associated with susceptibility to late-onset Alzheimer's disease.

Denise Harold
Richard Abraham
Julie Williams
Research06 Sept 2009
Nature Genetics

Volume: 41, P: 1088-1093
Uridine Diphosphate Hexoses in Leukocytes and Fibroblasts of Classic Galactosemics and Patients with Other Metabolic Diseases

James B Gibson
Robert A Reynolds
Stanton Segal
Research01 Nov 1994
Pediatric Research

Volume: 36, P: 613-618
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Philippe Amouyel, Julie Williams, Gerard Schellenberg, Sudha Seshadri and colleagues report a meta-analysis of genome-wide association studies for late-onset Alzheimer's disease in 17,008 cases and 37,154 controls with replication in an additional 8,572 cases and 11,312 controls. They identify 11 loci newly associated with Alzheimer's disease.

Jean-Charles Lambert
Carla A Ibrahim-Verbaas
Philippe Amouyel
Research27 Oct 2013
Nature Genetics

Volume: 45, P: 1452-1458
IMI European Lead Factory — democratizing access to high-throughput screening

The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to expand access to high-throughput screening. With many successes heading towards the clinic, the organization is broadening its approach to screening and partnering.

Philip S. Jones
Sylviane Boucharens
Jon S. B. de Vlieger
Comments & Opinion14 Dec 2021
Nature Reviews Drug Discovery

Volume: 21, P: 245-246
Female sex mitigates motor and behavioural phenotypes in TDP-43^Q331K knock-in mice

Jodie Watkins
Anshua Ghosh
Jemeen Sreedharan
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Impact of reduction of susceptibility to SARS-CoV-2 on epidemic dynamics in four early-seeded metropolitan regions

Thomas J. Barrett
Karen C. Patterson
Peter Krüger
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Vinod P. Balachandran
Marta Łuksza
Steven D. Leach
Research01 Nov 2017
Nature

Volume: 551, P: 512-516
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 and MS4A6A/MS4A4E associated with Alzheimer's disease and support for several additional susceptibility loci.

Paul Hollingworth
Denise Harold
Julie Williams
Research03 Apr 2011
Nature Genetics

Volume: 43, P: 429-435
Investigation of the interactions and electromagnetic shielding properties of graphene oxide/platinum nanoparticle composites prepared under low-dose gamma irradiation

Dejan Kepić
Miloš Milović
Svetlana Jovanović
ResearchOpen Access24 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
A quasi-solid-state high-rate lithium sulfur positive electrode incorporating Li₁₀GeP₂S₁₂

As the demand for efficient energy storage systems grows, lithium-sulfur batteries face challenges like the polysulfide shuttle effect and sluggish performance. Here, a high-rate quasi-solid-state sulfur positive electrode incorporating Li₁₀GeP₂S₁₂ enhances lithium-ion transport, achieving stable, high-capacity performance.

Boyi Pang
Huanxin Li
James B. Robinson
ResearchOpen Access05 Aug 2025
Communications Materials

Volume: 6, P: 1-9
Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn’s disease

Kay Diederen
Jia V. Li
Jurgen Seppen
ResearchOpen Access03 Nov 2020
Scientific Reports

Volume: 10, P: 1-17
A 130,000-year-old archaeological site in southern California, USA

Evidence of mastodon bone modifications for marrow extraction and/or tool production, found in the presence of hammerstones and anvils that showed use-wear and impact marks, suggest the presence of Homo in North America around 130 thousand years ago.

Steven R. Holen
Thomas A. Deméré
Kathleen A. Holen
Research27 Apr 2017
Nature

Volume: 544, P: 479-483
Estimation of a biofilm-specific reaction rate: kinetics of bacterial urea hydrolysis in a biofilm

James M Connolly
Benjamin Jackson
Robin Gerlach
ResearchOpen Access16 Sept 2015
npj Biofilms and Microbiomes

Volume: 1, P: 1-8
Molecular Analysis of the Hematopoietic Microenvironment

David A Williams
Research01 Nov 1994
Pediatric Research

Volume: 36, P: 557-560
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with Kras^G12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Pedro A. Pérez-Mancera
Alistair G. Rust
David A. Tuveson
Research29 Apr 2012
Nature

Volume: 486, P: 266-270
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

Mark Tuszynski and his colleagues show that brain-derived neurotrophic factor is neuroprotective and can improve cognition in rodent and primate models of Alzheimer's disease.

Alan H Nagahara
David A Merrill
Mark H Tuszynski
Research08 Feb 2009
Nature Medicine

Volume: 15, P: 331-337
Evidence of Oxidative Stress in Relation to Feeding Type During Early Life in Premature Infants

James K Friel
Bill Diehl-Jones
L Jackson Roberts II
Research01 Feb 2011
Pediatric Research

Volume: 69, P: 160-164
The GLP-1 receptor agonist, liraglutide, fails to slow disease progression in SOD1^G93A and TDP-43^Q331K transgenic mouse models of ALS

Amy Keerie
Heledd Brown-Wright
Richard J. Mead
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm

Richard A. Salisbury
Natalia Curto-Garcia
Andrew J. Innes
ResearchOpen Access12 Feb 2021
Leukemia

Volume: 35, P: 2424-2430
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Aleksander Skardal
Sean V. Murphy
Anthony Atala
ResearchOpen Access18 Aug 2017
Scientific Reports

Volume: 7, P: 1-16
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
Massive introgression drives species radiation at the range limit of Anopheles gambiae

José L. Vicente
Christopher S. Clarkson
João Pinto
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
Evidence for Abnormal Forward Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia

John C Hammond
Robert E McCullumsmith
James H Meador-Woodruff
Research23 Jun 2010
Neuropsychopharmacology

Volume: 35, P: 2110-2119
Spliceosome mutations are common in persons with myeloproliferative neoplasm-associated myelofibrosis with RBC-transfusion-dependence and correlate with response to pomalidomide

Onima Chowdhury
Jennifer O’Sullivan
James Vardiman
Research07 Aug 2020
Leukemia

Volume: 35, P: 1197-1202
PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages

Juliane Obst
Hazel L. Hall-Roberts
Emma Mead
ResearchOpen Access06 Oct 2021
Scientific Reports

Volume: 11, P: 1-17
Description of a new species of beaked whale (Berardius) found in the North Pacific

Tadasu K. Yamada
Shino Kitamura
Takashi F. Matsuishi
ResearchOpen Access30 Aug 2019
Scientific Reports

Volume: 9, P: 1-14
Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models

Chi-yang Chiu
Jeesun Jung
Ruzong Fan
Research21 Dec 2016
European Journal of Human Genetics

Volume: 25, P: 350-359
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study

Antoinette O’Connor
Thomas K. Karikari
Nick C. Fox
Research14 Jul 2020
Molecular Psychiatry

Volume: 26, P: 5967-5976
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Yixin Gao
Ting Wang
Ping Zeng
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
CXCR4 involvement in neurodegenerative diseases

Luke W. Bonham
Celeste M. Karch
P. Momeni
ResearchOpen Access11 Apr 2018
Translational Psychiatry

Volume: 8, P: 1-10

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