Nature Search

Long-term proliferation of mouse primordial germ cells in culture

James L. Resnick
Lynn S. Bixler
Peter J. Donovan
Research08 Oct 1992
Nature

Volume: 359, P: 550-551
Requirement for mast cell growth factor for primordial germ cell survival in culture

Susanna Dolci
Douglas E. Williams
Peter J. Donovan
Research29 Aug 1991
Nature

Volume: 352, P: 809-811
A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Zhijian Yang
Ilya M. Nasrallah
Balebail Ashok Raj
ResearchOpen Access03 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells

Design of cysteine-targeting analogs of a reversible SETDB1 triple Tudor domain (3TD) ligand, UNC6535, led to UNC10013, a potent covalent ligand with high selectivity. UNC10013 demonstrated allosteric inhibition of SETDB1-mediated Akt methylation in cells, a promising approach to SETDB1 therapeutics.

Mélanie Uguen
Devan J. Shell
Stephen V. Frye
ResearchOpen Access24 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded structures of this essential viral protein that are of interest for further drug development efforts.

Alice Douangamath
Daren Fearon
Martin A. Walsh
ResearchOpen Access07 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Trust in scientists and their role in society across 68 countries

What is the state of trust in scientists around the world? To answer this question, the authors surveyed 71,922 respondents in 68 countries and found that trust in scientists is moderately high.

Viktoria Cologna
Niels G. Mede
Rolf A. Zwaan
ResearchOpen Access20 Jan 2025
Nature Human Behaviour

Volume: 9, P: 713-730
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Keith Ligon, Adam Resnick, Rameen Beroukhim and colleagues identify MYB-QKI fusions in angiocentric gliomas and show that these rearrangements promote tumorigenesis through activation of MYB by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of QKI.

Pratiti Bandopadhayay
Lori A Ramkissoon
Adam C Resnick
Research01 Feb 2016
Nature Genetics

Volume: 48, P: 273-282
Hardware-efficient quantum error correction via concatenated bosonic qubits

Bosonic qubits can be engineered to feature intrinsic protection against certain kinds of errors, which makes quantum error correction across many bosonic qubits possible with less overhead.

Harald Putterman
Kyungjoo Noh
Oskar Painter
ResearchOpen Access26 Feb 2025
Nature

Volume: 638, P: 927-934
A molecular mechanism for long-term sensitization in Aplysia

Steven M. Greenberg
Vincent F. Castellucci
James H. Schwartz
Research03 Sept 1987
Nature

Volume: 329, P: 62-65
583 NENATAL DIACNOSTIC RELATED GROUPS (DRC) PROSPECTIVE PAYMENT SYSTEM FOR TERTIARY NEONATAL INTENSIVE CARE CENTERS

Micheal B Resnick
Mario Ariet
John S Curran
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 208
Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

A risk score based on a 34-gene signature for outcome prediction in meningioma was developed and validated in large multi-institutional cohorts and showed better performance in discriminating postoperative menignioma outcomes compared with existing meningioma classification systems.

William C. Chen
Abrar Choudhury
David R. Raleigh
Research09 Nov 2023
Nature Medicine

Volume: 29, P: 3067-3076
A mouse model for Prader-Willi syndrome imprinting-centre mutations

Tao Yang
Todd E. Adamson
Camilynn I. Brannan
Research01 May 1998
Nature Genetics

Volume: 19, P: 25-31
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Whole-genome sequence analysis identifies five independent risk loci for Lewy body dementia and demonstrates overlapping genetic architecture with Alzheimer’s and Parkinson’s diseases.

Ruth Chia
Marya S. Sabir
Sonja W. Scholz
Research15 Feb 2021
Nature Genetics

Volume: 53, P: 294-303
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes

Computational methods have made progress in improving classification accuracy and throughput of pathology workflows, but lack of interpretability remains a barrier to clinical integration. Here, the authors present an approach for predicting clinically-relevant molecular phenotypes from whole-slide histopathology images using human-interpretable image features.

James A. Diao
Jason K. Wang
Amaro Taylor-Weiner
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Structural consequences of turnover-induced homocitrate loss in nitrogenase

Biological nitrogen fixation is achieved by nitrogenase, but the mechanism remains enigmatic. Here, the authors report high resolution single particle cryoEM structures of homocitrate-compromised MoFe-proteins and unveil a new binding partner.

Rebeccah A. Warmack
Ailiena O. Maggiolo
Douglas C. Rees
ResearchOpen Access25 Feb 2023
Nature Communications

Volume: 14, P: 1-10
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation.

Owen S. Chapman
Jens Luebeck
Lukas Chavez
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2189-2199
Genetic sharing and heritability of paediatric age of onset autoimmune diseases

Autoimmune diseases are genetically complex disorders that affect up to 10% of the Western population. Here Li et al. quantify the heritability of a range of autoimmune diseases in the largest paediatric cohort examined to date, illustrating that genetic and non-genetic components variably contribute to the susceptibility of each disease.

Yun R. Li
Sihai D. Zhao
Hakon Hakonarson
ResearchOpen Access09 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

The tumor suppressor p53 is a master regulator of cellular stress response pathways, including cell cycle arrest and apoptosis. Here, the authors identify molecular mechanisms of p53 binding to high- and low-affinity p53 response elements in the genome, linked to cell cycle arrest and pro-apoptotic genes, respectively.

Marina Farkas
Hideharu Hashimoto
Steven B. McMahon
ResearchOpen Access20 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency with autoimmune comorbidity. Here, Li et al. show shared genetic susceptibility with autoimmune diseases, identifying the first non HLA risk locus at CLEC16Ain the largest CVID genetic study to date.

Jin Li
Silje F. Jørgensen
Eva Ellinghaus
Research20 Apr 2015
Nature Communications

Volume: 6, P: 1-7
Efficient electrocatalytic valorization of chlorinated organic water pollutant to ethylene

A molecular catalyst supported on carbon nanotubes efficiently transforms the notorious water pollutant 1,2-dichloroethane into a useful chemical feedstock ethylene in an electrified membrane filtration device.

Chungseok Choi
Xiaoxiong Wang
Hailiang Wang
Research19 Dec 2022
Nature Nanotechnology

Volume: 18, P: 160-167
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

A meta-analysis across ten pediatric autoimmune diseases reveals shared genetic architecture and novel susceptibility loci.

Yun R Li
Jin Li
Hakon Hakonarson
Research24 Aug 2015
Nature Medicine

Volume: 21, P: 1018-1027
Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

Structural, biophysical and genetic analyses reveal that Schizosaccharomyces pombe Ctp1 forms a flexible tetramer with multivalent DNA-binding and bridging activities that contribute to Ctp1's role in repair of DNA double-strand breaks.

Sara N Andres
C Denise Appel
R Scott Williams
Research12 Jan 2015
Nature Structural & Molecular Biology

Volume: 22, P: 158-166
Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

James A. Stefater III
Ian Lewkowich
Richard A. Lang
Research29 May 2011
Nature

Volume: 474, P: 511-515
The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough

John F Heidelberg
Rekha Seshadri
Claire M Fraser
ResearchOpen Access11 Apr 2004
Nature Biotechnology

Volume: 22, P: 554-559
A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

Edward C Thornborrow
Sejal Patel
James J Manfredi
Research18 Feb 2002
Oncogene

Volume: 21, P: 990-999
Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence

Mikhail A Nikiforov
Serena SS Kwek
Andrei V Gudkov
Research18 Dec 1997
Oncogene

Volume: 15, P: 3007-3012
Priapism pathophysiology: clues to prevention

A L Burnett
Research10 Oct 2003
International Journal of Impotence Research

Volume: 15, P: S80-S85
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

Sandro Santagata, Gad Getz and colleagues report the discovery of a recurrent mutation in the oncogene BRAF in papillary craniopharyngiomas that does not occur in the histologically related adamantinomatous form. Their results have the potential to aid in diagnosis and treatment of these intracranial tumors.

Priscilla K Brastianos
Amaro Taylor-Weiner
Sandro Santagata
Research12 Jan 2014
Nature Genetics

Volume: 46, P: 161-165
Expansion of Hematopoietic Progenitor Cell Populations in Stirred Suspension Bioreactors of Normal Human Bone Marrow Cells

Peter W. Zandstra
Connie J. Eaves
James M. Piret
Research01 Sept 1994
Bio/Technology

Volume: 12, P: 909-914
The impact of supportive nursing care on the needs of men with prostate cancer: a study across seven European countries

J Cockle-Hearne
F Charnay-Sonnek
S Faithfull
ResearchOpen Access24 Sept 2013
British Journal of Cancer

Volume: 109, P: 2121-2130
Migration, gene flow and reproductive isolation between and within morphotypes of the isopod Excirolana in two oceans

H A Lessios
James R Weinberg
Research01 Dec 1993
Heredity

Volume: 71, P: 561-573
Book Reviews

Robert Plomin
John Manning
James O Mcinerney
Books & Arts01 Jul 1998
Heredity

Volume: 81, P: 120-124
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, thereby mediating chromatin dynamics and stability, transcription, replication and DNA damage repair. Topoisomerases are targets of various anticancer drugs, and their deregulation can cause, in addition to cancer, neurodegenerative diseases and immune disorders.

Yves Pommier
Yilun Sun
John L. Nitiss
Reviews21 Sept 2016
Nature Reviews Molecular Cell Biology

Volume: 17, P: 703-721
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Debra Van Egeren
Khushi Kohli
Zenta Walther
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-6
Perceptions of science, science communication, and climate change attitudes in 68 countries – the TISP dataset

Niels G. Mede
Viktoria Cologna
Rolf A. Zwaan
ResearchOpen Access20 Jan 2025
Scientific Data

Volume: 12, P: 1-27
Editorial

James M Crawford
Editorial15 Dec 2005
Laboratory Investigation

Volume: 86, P: 4-8
Studying severe long COVID to understand post-infectious disorders beyond COVID-19

Petter Brodin
Giorgio Casari
Jean-Laurent Casanova
Correspondence05 Apr 2022
Nature Medicine

Volume: 28, P: 879-882
Blood-based microRNAs as biomarkers for the diagnosis of colorectal cancer: a systematic review and meta-analysis

Jane V Carter
Norman J Galbraith
Susan Galandiuk
ResearchOpen Access02 Feb 2017
British Journal of Cancer

Volume: 116, P: 762-774
Highly efficient GaAs solar cells by limiting light emission angle

Emily D Kosten
Jackson H Atwater
Harry A Atwater
ResearchOpen Access04 Jan 2013
Light: Science & Applications

Volume: 2, P: e45
The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis

N. A. J. Ryan
M. A. Glaire
E. J. Crosbie
ReviewsOpen Access14 May 2019
Genetics in Medicine

Volume: 21, P: 2167-2180
Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase

L E Giono
L Resnick-Silverman
J J Manfredi
Research14 Aug 2017
Oncogene

Volume: 36, P: 6762-6773

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