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Showing 1–3 of 3 results
Advanced filters: Author: James Londino Clear advanced filters

  • How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.

    • Joseph S. Bednash
    • Nathaniel Weathington
    • Rama K. Mallampalli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquitin ligase STUB1 as a negative regulator of IFNγ-R1/JAK1 expression in cancer cells.

    • Georgi Apriamashvili
    • David W. Vredevoogd
    • Daniel S. Peeper
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16