Search

Researchers demonstrated integrated non-magnetic isolators with 24.5-dB contrast, –2.16-dB insertion loss and 2-THz (16-nm) optical bandwidth.

Intrinsic optical bistability in Nd³⁺-doped KPb₂Cl₅ avalanching nanoparticles enables high-contrast switching between luminescent and non-luminescent states and transistor-like optical responses. A non-thermal mechanism is discussed and >200th-order optical nonlinearities are shown to be possible.

Phase transitions during which electrons recover their Dirac nature are shown to produce a spin resonance response that allows the characterization of spin and valley couplings in twisted bilayer graphene.

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

The tidal disruption event AT2019dsg is probably associated with a high-energy neutrino, suggesting that such events can contribute to the cosmic neutrino flux. The electromagnetic emission is explained in terms of a central engine, a photosphere and an extended synchrotron-emitting outflow.

Mixing with non-black carbon can enhance the radiative effect of black-carbon aerosols. Lab and field measurements of aerosol properties reveal that the mass ratio of black to non-black carbon determines the amount of enhancement.

A Brillouin laser-driven terahertz oscillator is developed. The phase noise level of the generated terahertz waves is less than –100 dBc Hz^–1, translating to timing noise below 10 as Hz^–1/2 at 10 kHz Fourier frequency, over a carrier frequency range from 300 GHz to 3 THz.

The development of active solids based on centimetre-scale building blocks incorporating odd elasticity shows that they can spontaneously undergo limit cycles of shape changes, leading to adaptive locomotion such as rolling and crawling.

Attosecond spectroscopy enables the study and manipulation of electron dynamics in solid state samples, enabling the potential realisation of ultrafast optoelectronics. Here, the authors report the generation and control of light-induced quantum tunnelling currents in graphene phototransistors with sub-femtosecond switching times under ambient conditions.

The authors showcase an optical-to-microwave conversion method using an optomechanical waveguide integrated with a piezoelectric transducer. The presented system allows bidirectional optical-to-microwave conversion with a quantum efficiency of up to—54.16 dB.

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

Using upgraded hardware of the multiuser Cold Atom Lab (CAL) aboard the International Space Station (ISS), Bose–Einstein condensates (BECs) of two atomic isotopes are simultaneously created and used to demonstrate interspecies interactions and dual species atom interferometry in space.

A high-resolution X-ray diffraction study of chromium and niobium diselenide traces the evolution of the ordering wavevector in charge and spin density waves, respectively, as a function of temperature and applied pressure.

Individually addressable ‘T centre’ photon-spin qubits are integrated in silicon photonic structures and their spin-dependent telecommunications-band optical transitions characterized, creating opportunities to construct silicon-integrated, telecommunications-band quantum information networks.

Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP granule-lysosome tethering and co-trafficking.

Therapeutic resistance to immune checkpoint inhibitor treatment is incompletely understood in adolescent and young-adult (AYA) patients with melanoma. Here, the authors demonstrate that AYA patients exhibit a unique stroma-infiltrating T cell immunogenomic profile compared with adults, which impacts on their responsiveness to immunotherapy.

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

The efficacy of epidural electrical stimulation (EES) to engage arm muscles and improve movement after spinal cord injury is still unclear. Here, the authors investigated how EES can recruit upper-limb motor neurons by combining computational modelling with experiments in non-human primates.

Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.

A sonochemical route rapidly synthesizes covalent organic frameworks (COFs) in aqueous solutions of acetic acid. This method has operational advantages compared with conventional solvothermal routes and yields COFs of higher crystallinity and porosity, and hence improved materials properties.

Authors report that long-term intestinal tissue maintenance in naked mole rats is achieved by having an expanded pool of slow-dividing adult stem cells while a higher proportion of differentiated cells confer enhanced function and protection to the intestinal mucosa.

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Star-forming galaxies trace cosmic history. Recent observational progress has led to the discovery and study of the earliest known galaxies, corresponding to a period when the Universe was only ∼800 million years old. Intense ultraviolet radiation from these early galaxies probably induced a major event in cosmic history: the reionization of intergalactic hydrogen.

Superluminescent diodes, that provide a broadband spectrum are typically used in spectral domain coherence tomography. Here, the authors use chipscale silicon nitride resonators to generate soliton microcombs with a lower noise flor that could substitute the diode sources.

This study reports unlimited near-infrared photoswitching in inorganic avalanching nanoparticles via a discrete shift of threshold intensity mediated by internal defect-based colour centres.

In a phase 1b trial, treatment of patients with muscle-invasive bladder cancer with intravesical oncolytic virus cretostimogene grenadenorepvec in combination with nivolumab was safe and led to encouraging preliminary clinical response rates.

A two-dimensional crystalline polymer of C₆₀, termed graphullerene, is synthesized by chemical vapour transport, and mechanically exfoliated to produce molecularly thin flakes with clean interfaces for potential optoelectronic applications.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

A new specific, small-molecule activator of the PI3Kα isoform (UCL-TRO-1938) identified through high-throughput screening can transiently activate PI3K signalling and biological responses in cells and tissues, with potential therapeutic applications in tissue protection and regeneration.

Spin models that can be emulated by quantum simulators are usually restricted to systems with conserved total magnetization. The tuning of photon-mediated interactions between atoms in a cavity enables the implementation of more general models also useful for quantum sensing tasks.

Quantum annealers hold promise of outperforming classical computers in solving hard optimization problems, but one main challenge is understanding the role of noise in quantum annealing. Here, the authors characterize the relevant noise sources in a tunable flux qubit, a building block for quantum annealers, and provide a benchmark for future work on highly-coherent quantum annealers.

Single-pass optical parametric amplification is demonstrated following propagation though an atomically thin semiconducting transition metal dichalcogenide. The demonstration may lead to atom-sized tunable light sources.