Nature Search

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease.

William J. Young
Najim Lahrouchi
Patricia B. Munroe
ResearchOpen Access01 Sept 2022
Nature Communications

Volume: 13, P: 1-18
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

Kirkland et al. identify conserved age-dependent nuclear remodeling in Drosophila cardiomyocytes, dependent on declining Lamin C. They show that Lamin C loss induces reversible heart dysfunction by repressing myogenic transcription factors.

Natalie J. Kirkland
Scott H. Skalak
Adam J. Engler
Research22 Dec 2022
Nature Aging

Volume: 3, P: 17-33
The transcription factor c-Myb regulates CD8⁺ T cell stemness and antitumor immunity

Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8⁺ T cell memory compartment.

Sanjivan Gautam
Jessica Fioravanti
Luca Gattinoni
Research18 Feb 2019
Nature Immunology

Volume: 20, P: 337-349
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.

William J. Young
Jeffrey Haessler
Patricia B. Munroe
ResearchOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1-16
25 Reduced Neonatal Candida Infection as a Result of Medical Practice Intervention

Maliha J Shareef
Kamlesh S Macwan
Sharon Klein
Research01 Oct 2005
Pediatric Research

Volume: 58, P: 820
Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation

Acute loss of CTCF disproportionately affects the transcription of genes that display promoter-proximal CTCF binding and are dependent on long-distance enhancers.

Naoki Kubo
Haruhiko Ishii
Bing Ren
Research04 Jan 2021
Nature Structural & Molecular Biology

Volume: 28, P: 152-161
miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8⁺ T cell fate

The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.

Yun Ji
Jessica Fioravanti
Luca Gattinoni
ResearchOpen Access14 May 2019
Nature Communications

Volume: 10, P: 1-12
Collaborative Quality Improvement for Neonatal Intensive Care. † 1026

Jeffrey D Horbar
Jeannette Rogowski
Roger F Soll
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 177
Inhaled Nitric Oxide in the Treatment of Moderate Persistent Pulmonary Hypertension of the Newborn: A Randomized Controlled, Multicenter Trial

H Farouk Sadiq
Gregory Mantych
James R Hocker
Research03 Apr 2003
Journal of Perinatology

Volume: 23, P: 98-103

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