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Showing 1–3 of 3 results
Advanced filters: Author: James R. Bayrer Clear advanced filters

  • Visceral pain and anxiety in mice are found to be associated with gut enterochromaffin cells, and genetic models for eliciting visceral hypersensitivity and studying the sex bias of gut pain are proposed.

    • James R. Bayrer
    • Joel Castro
    • David Julius
    Research
    Nature
    Volume: 616, P: 137-142

  • Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.

    • James R. Bayrer
    • Hongtao Wang
    • Holly A. Ingraham
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.

    • Candice B. Herber
    • William C. Krause
    • Holly A. Ingraham
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11