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Showing 1–10 of 10 results
Advanced filters: Author: James T Stivers Clear advanced filters

  • The enzyme subtiligase can be used to catalyze expressed protein ligation of proteins of interest with peptides lacking an N-terminal cysteine. This enables the analysis of protein modifications in the context of the native primary sequence.

    • Samuel H Henager
    • Nam Chu
    • Philip A Cole
    Research
    Nature Methods
    Volume: 13, P: 925-927

  • The enzyme uracil DNA glycosylase does not actively extrude just the uracil base from the DNA helix to facilitate its removal; instead, transient, passive opening of thymine: adenine and uracil: adenine base pairs allows both thymine and uracil to become extrahelical, but only uracil can subsequently fit in the active site.

    • Jared B. Parker
    • Mario A. Bianchet
    • James T. Stivers
    Research
    Nature
    Volume: 449, P: 433-437

  • AID/APOBEC deaminases, which convert cytosine bases to uracils in DNA and RNA, have recently been assigned a role in epigenetic regulation as components of DNA demethylation pathways. A systematic study shows that AID/APOBEC enzymes preferentially deaminate unmodified cytosine over its C5-modified forms, calling into question the plausibility of deaminase-mediated DNA demethylation pathways.

    • Christopher S Nabel
    • Huijue Jia
    • Rahul M Kohli
    Research
    Nature Chemical Biology
    Volume: 8, P: 751-758

  • DNA repair proteins require efficient pathways to search for DNA damage lesions within a large genome. Kinetic trapping experiments define the rates of human uracil DNA glycosylase hopping and sliding along damaged DNA substrates and highlight the role of the phosphodiester backbone in DNA sliding.

    • Joseph D Schonhoft
    • James T Stivers
    Research
    Nature Chemical Biology
    Volume: 8, P: 205-210

  • The MRN protein megacomplex mediates repair of double-stranded DNA breaks (DSBs) by tethering together broken ends of chromosomes and signaling a cascade of events required for DNA repair. The first small-molecule inhibitor that disrupts MRN function provides a valuable new tool for functional studies of DSB repair in cells.

    • James T Stivers
    News & Views
    Nature Chemical Biology
    Volume: 4, P: 86-88

  • Triptolide is a bioactive natural product isolated from plants used in traditional Chinese medicine. A target identification approach shows that triptolide modulates RNA transcription and nucleotide excision repair by covalent binding to the XPB subunit of the transcription factor TFIIH.

    • Denis V Titov
    • Benjamin Gilman
    • Jun O Liu
    Research
    Nature Chemical Biology
    Volume: 7, P: 182-188