MR1 molecules present bacterial metabolites to MAIT innate lymphocytes, but the processing and presentation pathway of these ligands are unclear. McCluskey, Rossjohn, Villadangos and colleagues demonstrate that MR1 ligands bind in the ER, which initiates trafficking to the plasma membrane and subsequent presentation.
- Hamish E G McWilliam
- Sidonia B G Eckle
- Jose A Villadangos
