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Showing 1–2 of 2 results
Advanced filters: Author: Jan Brazina Clear advanced filters

  • Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.

    • Hana Hanzlikova
    • Evgeniia Prokhorova
    • Keith W. Caldecott
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Adamowicz et al. report that toxic PARP1 activity, induced by ataxia-associated mutations in XRCC1, impairs the recovery of global transcription during DNA base excision repair by promoting aberrant recruitment and activity of the histone ubiquitin protease USP3.

    • Marek Adamowicz
    • Richard Hailstone
    • Keith W. Caldecott
    ResearchOpen Access
    Nature Cell Biology
    Volume: 23, P: 1287-1298