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Showing 1–4 of 4 results
Advanced filters: Author: Jan Gummert Clear advanced filters

  • In heart failure, increased CaMKII activity is decisively involved in arrhythmia formation. Here, the authors introduce the neuronal sodium channel NaV1.8 as a CaMKII downstream target as its specific knock-out reduces arrhythmias and improves survival in a CaMKII-overexpressing mouse model.

    • Philipp Bengel
    • Nataliya Dybkova
    • Samuel Sossalla
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • A time-resolved high-resolution map of human cardiac remodelling after myocardial infarction, integrating single-cell transcriptomic, chromatin accessibility and spatial transcriptomic data, provides a valuable resource for the field.

    • Christoph Kuppe
    • Ricardo O. Ramirez Flores
    • Rafael Kramann
    Research
    Nature
    Volume: 608, P: 766-777

  • In this Review, Kluin and colleagues describe the historical milestones and lessons learned in the development of total artificial hearts (TAHs), discuss the current generation of TAHs and their working mechanisms, and highlight challenges and future perspectives for the field, including new technologies that will promote TAH development in the coming decade.

    • Annemijn Vis
    • Maziar Arfaee
    • Jolanda Kluin
    Reviews
    Nature Reviews Cardiology
    Volume: 19, P: 813-828