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Showing 1–2 of 2 results
Advanced filters: Author: Jan Kosla Clear advanced filters

  • In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

    • Dominik Pfister
    • Nicolás Gonzalo Núñez
    • Mathias Heikenwalder
    ResearchOpen Access
    Nature
    Volume: 592, P: 450-456

  • Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and metastasis in vitro and in vivo.

    • Anna Lorentzen
    • Paul F. Becker
    • Mathias Heikenwalder
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-20