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Advanced filters: Author: Jan Kotarski Clear advanced filters

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis.

Ende Zhao
Tomasz Maj
Weiping Zou
Research02 Nov 2015
Nature Immunology

Volume: 17, P: 95-103
Epigenetic silencing of T_H1-type chemokines shapes tumour immunity and immunotherapy

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Dongjun Peng
Ilona Kryczek
Weiping Zou
Research26 Oct 2015
Nature

Volume: 527, P: 249-253

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Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

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Epigenetic silencing of T_H1-type chemokines shapes tumour immunity and immunotherapy