Nature Search

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

Caleb D. Marceau
Andreas S. Puschnik
Jan E. Carette
Research17 Jun 2016
Nature

Volume: 535, P: 159-163
Structures of the eukaryotic ribosome and its translational states in situ

The translational states of eukaryotic ribosomes have so far been only investigated in vitro. Here, authors obtained the 3.8 Å in situ 80S ribosome structure, the distribution of translational states and unique arrangement of rRNA expansion segments.

Patrick C. Hoffmann
Jan Philipp Kreysing
Martin Beck
ResearchOpen Access02 Dec 2022
Nature Communications

Volume: 13, P: 1-9
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

Karoutas et al. report lamin A/C as a non-histone target for the acetyltransferase MOF. They find that lamin A/C acetylation prevents nuclear envelope rupture and maintains nuclear integrity.

Adam Karoutas
Witold Szymanski
Asifa Akhtar
Research01 Oct 2019
Nature Cell Biology

Volume: 21, P: 1248-1260
Incidence and complications of cannula changes in long-term tracheotomized patients: a prospective observational study

Jan Wiefhoff
Oliver Jansen
Uwe Hamsen
Research16 Jul 2019
Spinal Cord

Volume: 58, P: 11-17
A CRISPR toolbox to study virus–host interactions

In this Review, Puschnik and colleagues discuss the technical aspects of using CRISPR–Cas technology in genome-scale knockout screens to study virus–host interactions, and they compare these screens with alternative genetic screening technologies.

Andreas S. Puschnik
Karim Majzoub
Jan E. Carette
Reviews19 Apr 2017
Nature Reviews Microbiology

Volume: 15, P: 351-364
Low Concentrations of Serum Haptoglobin in Mothers of Children with Haemolytic Disease of the Newborn

JAN PINTERA
Research13 Nov 1965
Nature

Volume: 208, P: 694-695
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial

In the homologous recombination repair-deficient population of TALAPRO-2, a placebo-controlled phase 3 trial, treatment of patients with metastatic castration-resistant prostate cancer with the poly(ADP-ribose) polymerase inhibitor talazoparib plus enzalutamide led to prolonged progression-free survival compared with placebo plus enzalutamide.

Karim Fizazi
Arun A. Azad
Neeraj Agarwal
ResearchOpen Access04 Dec 2023
Nature Medicine

Volume: 30, P: 257-264
Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial

In a biomarker-driven, outcome-adaptive platform trial for patients with metastatic castration-resistant prostate cancer, androgen receptor pathway inhibitors showed longer survival with respect to taxanes and physician’s choice treatment.

Bram De Laere
Alessio Crippa
Johan Lindberg
ResearchOpen Access20 Aug 2024
Nature Medicine

Volume: 30, P: 3291-3302
KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

The ability to visualise stochastic invasion events is limited in murine models of metastatic cancers. Here the authors use a transparent zebrafish epidermis model to follow the invasion events of K-Ras transformed epithelial cells and show that these cells invade through basal cell extrusion.

John Fadul
Teresa Zulueta-Coarasa
Jody Rosenblatt
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-9
Origin of Plastids and the Phylogeny of Algae

ROBERT EDWARD LEE
Research05 May 1972
Nature

Volume: 237, P: 44-46
An RNA-centric dissection of host complexes controlling flavivirus infection

A survey of the cellular RNA-binding proteins (RBPs) that interact with dengue virus and Zika virus genomic RNA identifies ribosome-binding protein 1 and vigilin as bona fide RBPs able to promote viral RNA translation, replication and stability.

Yaw Shin Ooi
Karim Majzoub
Jan E. Carette
Research05 Aug 2019
Nature Microbiology

Volume: 4, P: 2369-2382
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

Tokhir Dadaev
Edward J. Saunders
Zsofia Kote-Jarai
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-19
An automated platform for the enzyme-mediated assembly of complex oligosaccharides

An automated platform that can synthesize a wide range of complex glycans could greatly facilitate progress in glycoscience. Now, a fully automated process for enzyme-mediated oligosaccharide synthesis has been developed. This process uses glycosyltransferase-catalysed reactions performed in solution, with product purification being accomplished by solid phase extraction using a sulfonate tag.

Tiehai Li
Lin Liu
Geert-Jan Boons
Research21 Feb 2019
Nature Chemistry

Volume: 11, P: 229-236
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Analysis of snRNA genes in individuals with rare disorders identifies de novo and recurrent variants in RNU5B-1 and RNU5A-1, in addition to previously unreported cases with pathogenic or likely pathogenic variants in RNU4-2.

Caroline Nava
Benjamin Cogne
Christel Depienne
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1374-1388
Author Correction: Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial

Bram De Laere
Alessio Crippa
Johan Lindberg
Amendments and CorrectionsOpen Access28 Aug 2024
Nature Medicine

Volume: 30, P: 3381
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Research04 Jan 2021
Nature Genetics

Volume: 53, P: 65-75
Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors

Recombination during AAV production disrupts gene delivery in vivo. We present ABCD, a codon diversification strategy that prevents recombination, enabling reliable quantitative imaging using FRET sensors and gene expression in living animals.

Jan Dernic
Afroditi Eleftheriou
Luca Ravotto
ResearchOpen Access19 Aug 2025
Communications Biology

Volume: 8, P: 1-14
Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Accuracy and efficiency of drilling trajectories with augmented reality versus conventional navigation randomized crossover trial

Yao Li
Sergey Drobinsky
Behrus Puladi
ResearchOpen Access10 Nov 2024
npj Digital Medicine

Volume: 7, P: 1-13
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
91 A HIGHLY SENSITIVE RIA SYSTEM FOR HUMAN EPIDERMAL GROWTH FACTOR (EGF)

Carlos Callegari
Nilsa P Laborde
Delbert A Fisher
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 618
283 PULMONARY NEUROENDOCRINE CELLS (PNEC) IN NEONATAL RATS WITH CONGENITAL DIAPHRAGMATIC HERNIA (CDH)

Hanneke Usselstin
Donald G Perrin
Dick Libboer
Research01 Jul 1994
Pediatric Research

Volume: 36, P: 50
Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Fredrick R. Schumacher
Ali Amin Al Olama
Rosalind A. Eeles
Amendments and Corrections08 Jan 2019
Nature Genetics

Volume: 51, P: 363
Glycosylation in health and disease

Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer, xenotransplantation and glomerular filtration and the potential of ‘glycomedicine’.

Colin Reily
Tyler J. Stewart
Jan Novak
Reviews11 Mar 2019
Nature Reviews Nephrology

Volume: 15, P: 346-366
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology.

Fredrick R. Schumacher
Ali Amin Al Olama
Rosalind A. Eeles
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 928-936
Adaptive immune activation: glycosylation does matter

Margreet A Wolfert
Geert-Jan Boons
Reviews14 Nov 2013
Nature Chemical Biology

Volume: 9, P: 776-784
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Amendments and Corrections20 Jan 2021
Nature Genetics

Volume: 53, P: 413
On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

Nancy Hamel
Bing-Jian Feng
William D Foulkes
Research01 Dec 2010
European Journal of Human Genetics

Volume: 19, P: 300-306
Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

Camilo Perez
Martin Köhler
Kaspar P. Locher
ResearchOpen Access19 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
Amendments and CorrectionsOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-5
Investigating sensitivity to multi-domain prediction errors in chronic auditory phantom perception

Anusha Yasoda-Mohan
Jocelyn Faubert
Sven Vanneste
ResearchOpen Access14 May 2024
Scientific Reports

Volume: 14, P: 1-10
Facial model collection for medical augmented reality in oncologic cranio-maxillofacial surgery

Christina Gsaxner
Jürgen Wallner
Jan Egger
ResearchOpen Access09 Dec 2019
Scientific Data

Volume: 6, P: 1-7
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Lisa Borghini
Eileen Png
Peter Schermann
ResearchOpen Access06 May 2019
Scientific Reports

Volume: 9, P: 1-15

Search

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Structures of the eukaryotic ribosome and its translational states in situ

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

Incidence and complications of cannula changes in long-term tracheotomized patients: a prospective observational study

A CRISPR toolbox to study virus–host interactions

Low Concentrations of Serum Haptoglobin in Mothers of Children with Haemolytic Disease of the Newborn

First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial

Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial

KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Origin of Plastids and the Phylogeny of Algae

An RNA-centric dissection of host complexes controlling flavivirus infection

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

An automated platform for the enzyme-mediated assembly of complex oligosaccharides

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

Author Correction: Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Accuracy and efficiency of drilling trajectories with augmented reality versus conventional navigation randomized crossover trial

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

91 A HIGHLY SENSITIVE RIA SYSTEM FOR HUMAN EPIDERMAL GROWTH FACTOR (EGF)

283 PULMONARY NEUROENDOCRINE CELLS (PNEC) IN NEONATAL RATS WITH CONGENITAL DIAPHRAGMATIC HERNIA (CDH)

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Glycosylation in health and disease

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Adaptive immune activation: glycosylation does matter

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Investigating sensitivity to multi-domain prediction errors in chronic auditory phantom perception

Facial model collection for medical augmented reality in oncologic cranio-maxillofacial surgery

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

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