Positron emission tomography imaging is an increasingly important technology in drug discovery and development, so there is an urgent need for logistically simple processes that allow access to [18F]CF3 (hetero)arenes. Here, a late-stage [18F]trifluoromethylation of (hetero)aryl iodides from [18F]fluoride and commercially available reagents is described, a process that relies on the in situ preparation of [18F]CuCF3.
- Mickael Huiban
- Matthew Tredwell
- Jan Passchier
