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Showing 1–3 of 3 results
Advanced filters: Author: Jan Peychl Clear advanced filters

  • Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defining the composition of multicomponent condensates can be inferred precisely from the intersection of a spectrometrically determined tie-line with an isorefractive line obtained from quantitative phase imaging.

    • Patrick M. McCall
    • Kyoohyun Kim
    • Jan Brugués
    ResearchOpen Access
    Nature Chemistry
    P: 1-12

  • Ten years of development in light-sheet microscopy have led to spectacular demonstrations of its capabilities. The technology is ready to assist biologists in tackling scientific problems, but are biologists ready for it? Here we discuss the interdisciplinary challenges light-sheet microscopy presents for biologists and highlight available resources.

    • Emmanuel G Reynaud
    • Jan Peychl
    • Pavel Tomancak
    Comments & Opinion
    Nature Methods
    Volume: 12, P: 30-34

  • The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis; using in vivo RNA interference and mathematical modelling it is shown here that the endolysosomal system is resilient to loss of Rab5 until its concentration drops below a critical level, at which point endosomes are lost, leading to increased serum low-density lipoprotein levels, alterations in metabolism and hepatocellular polarity.

    • Anja Zeigerer
    • Jerome Gilleron
    • Marino Zerial
    Research
    Nature
    Volume: 485, P: 465-470