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Nature Metabolism (4)
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Showing 1–10 of 10 results

Advanced filters: Author: Jan-Bernd Funcke Clear advanced filters

Much ado about NAA-thing

A recent study in Nature Metabolism by Felix et al. reveals that the breakdown of N-acetylaspartate (NAA) by the enzyme aspartoacylase (encoded by Aspa) in adipocytes has a crucial role in regulating circulating NAA levels, maintaining systemic glucose homeostasis and controlling postprandial body temperature.

Jan-Bernd Funcke
Philipp E. Scherer
News & Views23 Jul 2025
Nature Metabolism

Volume: 7, P: 1498-1500
ETP-specific-knockout mice reveal endotrophin as a key regulator of kidney fibrosis in ischemia–reperfusion injury models

Dae-Seok Kim
Jan-Bernd Funcke
Philipp E. Scherer
ResearchOpen Access07 Nov 2025
Experimental & Molecular Medicine

Volume: 57, P: 2475-2486
Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency

Katja Kohlsdorf
Adriana Nunziata
Martin Wabitsch
Research27 Feb 2018
International Journal of Obesity

Volume: 42, P: 1602-1609
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels

PAQR4 regulates cellular ceramide synthesis and accumulation to mediate adipose tissue function, glucose homoeostasis and, thus, systemic metabolic health.

Qingzhang Zhu
Shiuhwei Chen
Philipp E. Scherer
Research03 Jul 2024
Nature Metabolism

Volume: 6, P: 1347-1366
VCAM-1/Ezrin axis antagonizes myocardial damage in ischemia-reperfusion injury

Anwarul Ferdous
Ariel Diaz
Joseph A. Hill
Research28 Nov 2025
Cell Death & Differentiation

P: 1-12
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations

Using inducible transgenic mouse models, Joffin, Gliniak and colleagues demonstrate that altering mitochondrial iron levels in adipose tissue macrophages has profound effects on systemic metabolism in male mice.

Nolwenn Joffin
Christy M. Gliniak
Philipp E. Scherer
Research03 Nov 2022
Nature Metabolism

Volume: 4, P: 1474-1494
Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity

Amyloid precursor protein contributes to the pathogenesis of Alzheimer’s disease. An et al. show that its increase in white adipose tissue under a high-fat diet promotes obesity and impairs mitochondrial function by blocking the protein import machinery.

Yu A. An
Clair Crewe
Philipp E. Scherer
Research13 Dec 2019
Nature Metabolism

Volume: 1, P: 1243-1257
miR-146a-mediated suppression of the inflammatory response in human adipocytes

Julian Roos
Eveliina Enlund
Pamela Fischer-Posovszky
ResearchOpen Access06 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes

Verena Zoller
Jan-Bernd Funcke
Pamela Fischer-Posovszky
ResearchOpen Access18 Jul 2017
Scientific Reports

Volume: 7, P: 1-12
TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors

Verena Zoller
Jan-Bernd Funcke
Pamela Fischer-Posovszky
ResearchOpen Access13 Oct 2016
Cell Death & Disease

Volume: 7, P: e2412