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Showing 1–3 of 3 results
Advanced filters: Author: Jan-Hannes Schäfer Clear advanced filters

  • Using cryo-electron microscopy, Schäfer et al. solved the structure of the yeast ceramide synthase complex, consisting of Lip1, Lag1 and Lac1 subunits. They found that fumonisin B1 binds competitively at a key site, suggesting a mechanism for ceramide synthesis.

    • Jan-Hannes Schäfer
    • Lena Clausmeyer
    • Florian Fröhlich
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 441-449

  • Sphingolipids are structural membrane components produced by the serine palmitoyl transferase (SPT). Here, the authors solved the cryo EM structure of the ceramide bound yeast SPOTS complex. This explains how ceramide regulates the activity of the yeast SPT complex.

    • Jan-Hannes Schäfer
    • Carolin Körner
    • Florian Fröhlich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in Parkinson’s disease. Here, Dobert et al. leveraged cryo-EM to solve the protein structure of the enzyme in complex with its lysosomal transporter LIMP-2.

    • Jan Philipp Dobert
    • Jan-Hannes Schäfer
    • Philipp Arnold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14