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Showing 1–6 of 6 results
Advanced filters: Author: Jana F. Liewald Clear advanced filters

  • Optogenetic actuation regimes are often static, which allows perturbation, but not true control of neuronal activity. Here, the authors describe an all-optical method for bidirectional steering of membrane potential, in closed loop, in C. elegans muscles and neurons, and rat hippocampal slice culture. The ‘optogenetic voltage clamp’ uses two microbial rhodopsin actuators and the rhodopsin voltage indicator QuasAr.

    • Amelie C. F. Bergs
    • Jana F. Liewald
    • Alexander Gottschalk
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Using both behavioral and electrophysiological readouts, Channelrhodopsin-2, a light-gated cation channel, is applied to the study of synaptic function in Caenorhabditis elegans.

    • Jana F Liewald
    • Martin Brauner
    • Alexander Gottschalk
    Research
    Nature Methods
    Volume: 5, P: 895-902

  • A light-activated chloride pump that occurs naturally in bacteria can be transfected into neurons, thereby permitting inhibition of neural activity on a millisecond timescale. This complements an existing tool for activating neurons through a photoactivatable algal channel.

    • Feng Zhang
    • Li-Ping Wang
    • Karl Deisseroth
    Research
    Nature
    Volume: 446, P: 633-639

  • Existing optogenetic silencing methods affect membrane potential, biochemistry or protein integrity. Here, the authors demonstrate an approach for silencing synaptic transmission that combines fast activation and reversibility, by using nondisruptive, reversible, light-evoked clustering of synaptic vesicles, which they validate in Caenorhabditis elegans, zebrafish, and murine cell culture.

    • Dennis Vettkötter
    • Martin Schneider
    • Alexander Gottschalk
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron. Its optogenetic stimulation caused acute and persistent inhibition of locomotion, and brief intrinsic RIS activity preceded slowing.

    • Wagner Steuer Costa
    • Petrus Van der Auwera
    • Alexander Gottschalk
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431