Secondary mutations can drive the transformation of pre-leukemic clones that carry ETV6-RUNX1 translocations. Müschen and colleagues show that repeated inflammatory episodes induce aberrant coexpression of the DNA recombinases RAG and AID to promote the development of acute lymphoblastic leukemia.
- Srividya Swaminathan
- Lars Klemm
- Markus Müschen
