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Showing 1–4 of 4 results
Advanced filters: Author: Jana Zecha Clear advanced filters

  • Post-translational modifications (PTMs) can regulate cellular protein function but their global impact on protein turnover is largely unknown. Here, the authors develop proteomic workflows to profile PTM-resolved protein turnover and analyze the effects of phosphorylation, acetylation and ubiquitination.

    • Jana Zecha
    • Wassim Gabriel
    • Bernhard Kuster
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Mass spectrometry-based proteomics typically relies on highly sensitive nano-flow liquid chromatography (LC) but this can reduce robustness and reproducibility. Here, the authors show that micro-flow LC enables robust and reproducible high-throughput proteomics experiments at a very moderate loss of sensitivity.

    • Yangyang Bian
    • Runsheng Zheng
    • Bernhard Kuster
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across different cell lines

    • Martin Frejno
    • Chen Meng
    • Bernhard Kuster
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The meltome atlas compiles the thermal stability of 48,000 proteins across 13 species ranging from archaea to humans, providing a resource for analyzing protein stability in the context of function and interactions.

    • Anna Jarzab
    • Nils Kurzawa
    • Bernhard Kuster
    Research
    Nature Methods
    Volume: 17, P: 495-503