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Showing 1–3 of 3 results
Advanced filters: Author: Jane Cheeseman Clear advanced filters

  • Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL-7-related autoimmunity.

    • Hussein Al-Mossawi
    • Nicole Yager
    • Benjamin P. Fairfax
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • A new model for translational research and drug repositioning has recently been established based on three-way partnerships between public funders, the pharmaceutical industry and academic investigators. This article discusses the progress with two pioneering initiatives — one involving the UK Medical Research Council and one involving the US National Center for Advancing Translational Sciences — and the unique requirements and challenges for this model.

    • Donald E. Frail
    • Madeleine Brady
    • Craig D. Wegner
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 833-841