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Showing 1–5 of 5 results

Advanced filters: Author: Janet A. Willment Clear advanced filters

Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing

Here, Reedy et al. use a human airway culture model to show that fungal melanin blocks the secretion of pro-inflammatory chemokines resulting in diminished immune responses to Aspergillus fumigatus and Pseudomonas aeruginosa.

Jennifer L. Reedy
Kirstine Nolling Jensen
Jatin M. Vyas
ResearchOpen Access10 Jul 2024
Nature Communications

Volume: 15, P: 1-16
Recognition and control of neutrophil extracellular trap formation by MICL

How MICL recognizes and autoregulates the formation of neutrophil extracellular traps is explored in mouse models and human patients where disease severity is associated with aberrant neutrophil extracellular trap formation.

Mariano Malamud
Lauren Whitehead
Gordon D. Brown
ResearchOpen Access14 Aug 2024
Nature

Volume: 633, P: 442-450
Dectin-1 is required for β-glucan recognition and control of fungal infection

Philip R Taylor
S Vicky Tsoni
Gordon D Brown
Research10 Dec 2006
Nature Immunology

Volume: 8, P: 31-38
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

Mark H. T. Stappers
Alexandra E. Clark
Gordon D. Brown
Research28 Feb 2018
Nature

Volume: 555, P: 382-386
C-type lectins in immunity and homeostasis

Recently discovered roles for C-type lectins in development, homeostasis, cell death, cancer and autoimmune and inflammatory diseases extend the functions of this superfamily beyond their well-recognized involvement in antimicrobial responses.

Gordon D. Brown
Janet A. Willment
Lauren Whitehead
Reviews26 Mar 2018
Nature Reviews Immunology

Volume: 18, P: 374-389