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Showing 1–3 of 3 results
Advanced filters: Author: Janet Leatherwood Clear advanced filters

  • Messenger RNAs don't usually correspond exactly to DNA — portions of the primary transcript, known as introns, are removed by splicing. A study reveals new ways in which splicing can be regulated.

    • Bruce Futcher
    • Janet K. Leatherwood
    News & Views
    Nature
    Volume: 455, P: 885-886

  • Meiosis is a highly conserved and tightly regulated process in which one round of DNA synthesis is followed by two rounds of division. By studying the expression of crs1 pre-mRNA, a meiotic cyclin in fission yeast, Wise and co-workers found that increased RNA accumulation during meiosis is not due to an increase in transcription but rather is a result of RNA processing and turnover. Moreover, they found that polyadenylation of crs1 is linked to splicing, a coupling previously thought to occur only in mammals. They suggest that this highly integrated crs1 regulatory system may allow a rapid response to adverse conditions.

    • David S McPheeters
    • Nicole Cremona
    • Jo Ann Wise
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 255-264