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Showing 1–3 of 3 results
Advanced filters: Author: Janett Göhring Clear advanced filters
  • Mechanical forces at the immunological synapse are believed to influence antigen recognition by the T cell receptor (TCR). Here the authors analyse these forces at single-molecule resolution to show that the ligand-engaged TCR of CD4+ T-cells create a stable environment with only a small fraction of TCR:pMHC complexes experiencing mechanistic forces at any given time during antigen surveillance and upon T-cell activation.

    • Lukas Schrangl
    • Florian Kellner
    • Janett Göhring
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level.

    • Janett Göhring
    • Florian Kellner
    • Gerhard J. Schütz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.

    • Mario Brameshuber
    • Florian Kellner
    • Johannes B. Huppa
    Research
    Nature Immunology
    Volume: 19, P: 487-496