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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment

This work compares the preclinical lung biodistribution and efficacy profile of inhaled anti-CCN2 (cellular communication network factor 2) Anticalin® protein PRS-220 for the treatment for idiopathic pulmonary fibrosis (IPF) compared to systemic delivery of a CCN2 inhibitor.

Vanessa Neiens
Eva-Maria Hansbauer
Marina Pavlidou
ResearchOpen Access05 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-blocking drugs: a histone demethylase inhibitor ML324 and the antitubercular SQ109.

Janette Reader
Mariëtte E. van der Watt
Lyn-Marié Birkholtz
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Most compounds active against asexual blood stage malaria parasites show reduced activity against gametocytes. Here the authors directly compare asexual and gametocytocidal activity of 80 compounds and identify physicochemical properties that influence dual activity.

Mariska Naude
Ashleigh van Heerden
Lyn-Marié Birkholtz
ResearchOpen Access15 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Decoquinate is a drug used in veterinary practice, which displays antimalarial activity in vitro but has poor bioavailability. Here, the authors convert decoquinate into more soluble amide and carbamate derivatives and assess their efficacy against tuberculosis bacteria and apicomplexan parasites.

Richard M. Beteck
Ronnett Seldon
Richard K. Haynes
ResearchOpen Access02 Oct 2018
Communications Chemistry

Volume: 1, P: 1-11
Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts

Qi Ge
Ling Chen
Brian Oliver
ResearchOpen Access02 Apr 2015
Scientific Reports

Volume: 5, P: 1-6
Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

Riëtte van Biljon
Jandeli Niemand
Lyn-Marié Birkholtz
ResearchOpen Access08 Nov 2018
Scientific Reports

Volume: 8, P: 1-14
Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Nanika Coetzee
Hilde von Grüning
Lyn-Marié Birkholtz
ResearchOpen Access11 Feb 2020
Scientific Reports

Volume: 10, P: 1-11

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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites

Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

Search

Quick links