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Showing 1–3 of 3 results
Advanced filters: Author: Janghoo Lim Clear advanced filters

  • Spinocerebellar ataxia type 1 (SCA1) is an inherited neurodegenerative disease caused by expansion of a glutamine-encoding repeat in ataxin 1. The expanded polyglutamine tract can affect the function of the ataxin1 protein in different ways, depending on the protein partners ataxin1 is associated with. This paper shows that polyglutamine expansion in one and the same protein can cause gain of function and loss of function toxicity at the same time.

    • Janghoo Lim
    • Juan Crespo-Barreto
    • Huda Y. Zoghbi
    Research
    Nature
    Volume: 452, P: 713-718

  • In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.

    • Leon Tejwani
    • Janghoo Lim
    Research Highlights
    Cell Research
    Volume: 27, P: 1403-1404