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Nature Structural & Molecular Biology (3)
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Showing 1–6 of 6 results

Advanced filters: Author: Janice M. Reimer Clear advanced filters

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge

Using cryo-EM, Karasmanis, Reimer, and Kendrick et al. reveal a Lis1-mediated dynein dimer, termed Chi, that serves as intermediate state in relieving dynein’s autoinhibition.

Eva P. Karasmanis
Janice M. Reimer
Andres E. Leschziner
ResearchOpen Access24 Aug 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1357-1364
Structure of LRRK1 and mechanisms of autoinhibition and activation

Reimer et al. used cryo-EM and cellular assays to reveal the structural and regulatory features that distinguish LRRK1 from LRRK2, and placed these features in the context of the evolution of the LRRK family of proteins.

Janice M. Reimer
Andrea M. Dickey
Andres E. Leschziner
ResearchOpen Access19 Oct 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1735-1745
Structural insights into assembly and function of the RSC chromatin remodeling complex

Cryo-EM and biochemical analyses of a subcomplex of S. cerevisiae RSC comprising its ATPase Sth1, Arp7, Arp9 and Rtt102 show that large conformational changes are part of Sth1 regulation and advance a mechanistic understanding of RSC complex assembly.

Richard W. Baker
Janice M. Reimer
Andres E. Leschziner
Research07 Dec 2020
Nature Structural & Molecular Biology

Volume: 28, P: 71-80
Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

WebX-ray crystal structures are presented of each major step of the assembly-line synthesis by the initiation module of the nonribosomal peptide synthetase (NRPS) LgrA; the structures reveal large conformational changes, demonstrating a requirement for NRPSs to be very dynamic.

Janice M. Reimer
Martin N. Aloise
T. Martin Schmeing
Research13 Jan 2016
Nature

Volume: 529, P: 239-242
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder

Azmeraw T. Amare
Anbupalam Thalamuthu
Bernhard T. Baune
ResearchOpen Access11 Jul 2023
Molecular Psychiatry

Volume: 28, P: 5251-5261
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472