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Characterizing SARS-CoV-2 neutralization profiles after bivalent boosting using antigenic cartography

Antigenic characterization of new SARS-CoV-2 variants is important to evaluate population immunity and the need for vaccine updates. Here, neutralizing antibodies against newly emerged Omicron variants were analysed in bivalently boosted individuals.

Annika Rössler
Antonia Netzl
Janine Kimpel
ResearchOpen Access26 Aug 2023
Nature Communications

Volume: 14, P: 1-9
BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants

SARS-CoV-2 omicron variant BA.1 has shown increased transmissibility and immune escape, relative to previous SARS-CoV-2 variants. In this study, authors utilise antigenic cartography to characterise the neutralisation profiles of omicron sub-lineages, BA.2 and BA.5, in comparison to BA.1 and pre-omicron variants.

Annika Rössler
Antonia Netzl
Janine Kimpel
ResearchOpen Access13 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Impacts of rapid mass vaccination against SARS-CoV2 in an early variant of concern hotspot

Schwaz, Austria, experienced SARS-CoV-2 outbreaks caused by variants of concern in early 2021 and conducted a mass vaccination campaign in response, with 70% of the adult population vaccinated after 5 days. Here, the authors show that this campaign resulted in reduced infections and hospitalisations.

Jörg Paetzold
Janine Kimpel
Hannes Winner
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-7
A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflamed tumours proinflammatory and less resistant to checkpoint blockade therapy.

Krishna Das
Elodie Belnoue
Guido Wollmann
ResearchOpen Access31 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

Annika Rössler
Antonia Netzl
Janine Kimpel
ResearchOpen Access18 May 2024
npj Vaccines

Volume: 9, P: 1-4
High SARS-CoV-2 seroprevalence in children and adults in the Austrian ski resort of Ischgl

Knabl et al. perform a seroepidemiological study in the Austrian ski resort Ischgl, where a super-spreader event lead to a SARS-CoV-2 outbreak. Through mathematical modelling, they find that the subsequent decline in viral transmission was most likely a combined effect of high seropositivity and the implementation of non-pharmaceutical interventions.

Ludwig Knabl
Tanmay Mitra
Dorothee von Laer
ResearchOpen Access30 Jun 2021
Communications Medicine

Volume: 1, P: 1-9
Loss of the orphan nuclear receptor NR2F6 enhances CD8⁺ T-cell memory via IFN-γ

Bojana Jakic
William J. Olson
Natascha Hermann-Kleiter
ResearchOpen Access15 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-16
The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer

Liesa-Marie Schreiber
Carles Urbiola
Guido Wollmann
ResearchOpen Access18 Sept 2019
British Journal of Cancer

Volume: 121, P: 647-658

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