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Showing 1–6 of 6 results
Advanced filters: Author: Janine L. Coombes Clear advanced filters
  • A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

    • Xinhe Zhang
    • Jakob Grove
    • Varun Warrier
    ResearchOpen Access
    Nature
    Volume: 646, P: 1146-1155
  • Pre-clinical studies have demonstrated the anti-tumor activity of selective inhibitors of CDK7, including samuraciclib. Here the authors report the results from dose escalation and two expansion cohorts in patients with breast cancer of a multi-modular Phase I clinical trial of samuraciclib as anti-cancer treatment.

    • R. C. Coombes
    • Sacha Howell
    • Matthew G. Krebs
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10
  • Advances in microscopy and labelling technologies have provided new opportunities for visualizing host–pathogen interactions in action. This Review highlights some of the insights gained from imaging immune responses to pathogens in the context of intact tissues.

    • Janine L. Coombes
    • Ellen A. Robey
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 353-364
  • A delicate balance between tolerance to commensal bacteria and immunity to pathogens occurs in the intestine. Intestinal dendritic cells have a central role in maintaining this balance and, as described here, some of the molecular pathways involved have recently been resolved.

    • Janine L. Coombes
    • Fiona Powrie
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 435-446