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Showing 1–2 of 2 results
Advanced filters: Author: Janine M. Lamonica Clear advanced filters

  • CRISPR-Cas9 has been utilized, through the fusion of catalytic dead nuclease with chromatin-remodellers, to modify the epigenetic state of specific loci. Here the authors manipulate locus-specific histone acetylation and describe the parameters that need to be considered for its use.

    • Deborah Y. Kwon
    • Ying-Tao Zhao
    • Zhaolan Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Transcriptomic profiling using a newly-developed cre-inducible method to biotinylate wild-type and mutant MeCP2 protein highlights the cellular heterogeneity of transcriptional changes in rodent models of Rett Syndrome, including cell-type- and subcellular compartment-specific differences in male brains and X-linked mosaicism in female brains.

    • Brian S Johnson
    • Ying-Tao Zhao
    • Zhaolan Zhou
    Research
    Nature Medicine
    Volume: 23, P: 1203-1214