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Personalized phosphoproteomics identifies functional signaling

Functionally relevant phosphorylation sites are detected by integrating phosphoproteomic and phenotypic data.

Elise J. Needham
Janne R. Hingst
Sean J. Humphrey
Research02 Dec 2021
Nature Biotechnology

Volume: 40, P: 576-584
Effects of seven days’ fasting on physical performance and metabolic adaptation during exercise in humans

During starvation, muscle strength and endurance, are still critical for survival. Seven days of complete fasting did not reduce maximal strength in leg muscles, but maximal endurance capacity was decreased because carbohydrate oxidation was restrained.

Kristoffer J. Kolnes
Emelie T. F. Nilsen
Jørgen Jensen
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise

In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, yet exercise mitigates these defects, offering potential for personalized lifestyle interventions.

Jonas M. Kristensen
Rasmus Kjøbsted
Jørgen F. P. Wojtaszewski
ResearchOpen Access31 Oct 2024
Nature Metabolism

Volume: 6, P: 2254-2266

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