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Showing 1–4 of 4 results
Advanced filters: Author: Janusz Puc Clear advanced filters

  • Although the Tetrahymena group I intron was the first RNA catalyst discovered, important mechanistic details remain ambiguous. Now six different conformational states of Tetrahymena group I intron self-splicing and an unexpected pseudoknotted structure are resolved by cryogenic electron microscopy.

    • Bingnan Luo
    • Chong Zhang
    • Zhaoming Su
    Research
    Nature Catalysis
    Volume: 6, P: 298-309

  • The clinical benefits of chimaeric antigen receptor (CAR) T therapy are limited by ‘on-target, off-tumour’ effects. In this study, the authors describe a strategy that promotes the recognition of antigen on tumour, but not normal, cells by combining affinity tuning with inducible interleukin-12 expression.

    • Yanping Yang
    • Huan Yang
    • Moonsoo M. Jin
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • A new study reveals that the HMG-box transcription factor SOX2 coupled with the chromatin remodeling helicase CHD7 cooperatively regulate target genes that are essential during neural stem cell development. Notably, this complex controls the expression of several disease-associated genes, suggesting a possible mechanistic connection between five seemingly unrelated human genetic disorders.

    • Janusz Puc
    • Michael G Rosenfeld
    News & Views
    Nature Genetics
    Volume: 43, P: 505-506

  • Recent evidence indicates that controlled generation of DNA breaks, accompanied by activation of DNA damage repair pathways, can regulate transcription through promoter and enhancer activation and the relief of DNA torsional stress.

    • Janusz Puc
    • Aneel K. Aggarwal
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 471-476