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Showing 1–14 of 14 results
Advanced filters: Author: Jared Rutter Clear advanced filters

  • The field of bioenergetics is rapidly expanding with new discoveries of mechanisms and potential therapeutic targets. The 2023 Keystone symposium on ‘Bioenergetics in Health and Disease’, which was jointly held with the symposium ‘Adipose Tissue: Energizing Good Fat’, consisted of a powerhouse line-up of researchers who shared their insights.

    • Melia Granath-Panelo
    • Anna Krook
    • Shingo Kajimura
    Comments & Opinion
    Nature Reviews Endocrinology
    Volume: 19, P: 250-251

  • Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

    • Aimee Flores
    • John Schell
    • William E. Lowry
    Research
    Nature Cell Biology
    Volume: 19, P: 1017-1026

  • The ribosome-associated quality control complex (RQC) functions to disassemble stalled ribosomes. Here the authors find that the tRNA hydrolase Vms1 is involved in the release of nascent peptide from stalled ribosomes.

    • Olga Zurita Rendón
    • Eric K. Fredrickson
    • Jared Rutter
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9

  • The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.

    • Qi Hao
    • Jin-Mi Heo
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Metabolic substrate partitioning underlies myocardial homeostatic capacity and adaptation to stress. Zhang et al. show that decreasing mitochondrial pyruvate carrier expression redirects glycolytic intermediates and leads to heart failure, which is prevented or reversed with a high-fat or ketogenic diet.

    • Yuan Zhang
    • Paul V. Taufalele
    • E. Dale Abel
    Research
    Nature Metabolism
    Volume: 2, P: 1248-1264

  • Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

    • John C. Schell
    • Jared Rutter
    News & Views
    Nature Cell Biology
    Volume: 19, P: 589-591

  • Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic reactions and other processes in development, homeostasis and disease. As such, metabolites can confer adaptive responses to environmental changes.

    • Steven Andrew Baker
    • Jared Rutter
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 355-374