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Showing 1–5 of 5 results
Advanced filters: Author: Jared W Ellefson Clear advanced filters
  • Translational reprogramming, which enables site-specific incorporation of non-natural amino acids into proteins, offers practical tools for studying protein function but also provides insights into the genetic code. Bacteriophages engineered with a 21-amino-acid genetic code make use of the additional noncanonical amino acid during in vitro evolution.

    • Michael J Hammerling
    • Jared W Ellefson
    • Jeffrey E Barrick
    Research
    Nature Chemical Biology
    Volume: 10, P: 178-180
  • Directed evolution of Trp repressor (TrpR) variants that are responsive to halogenated tryptophan analogs and recognize new operator sites serve as useful components for constructing complex gene expression networks.

    • Jared W. Ellefson
    • Michael P. Ledbetter
    • Andrew D. Ellington
    Research
    Nature Chemical Biology
    Volume: 14, P: 361-367
  • Expansion of the genetic code to noncanonical amino acids (NCAAs) has been limited by the lack of evolutionary pressure for organismal dependence on the NCAA. Linking bacterial survival to an engineered β-lactamase that requires a non-natural tyrosine analog engenders diverse bacteria with a stable, expanded genetic code.

    • Drew S Tack
    • Jared W Ellefson
    • Andrew D Ellington
    Research
    Nature Chemical Biology
    Volume: 12, P: 138-140