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Showing 1–2 of 2 results
Advanced filters: Author: Jarny Choi Clear advanced filters

  • The MYST acetyltransferase HBO1 is a critical regulator in maintaining leukaemia stem cells, and a small-molecule inhibitor of HBO1 is developed that shows efficacy against a range of acute myeloid leukaemia cells.

    • Laura MacPherson
    • Juliana Anokye
    • Mark A. Dawson
    Research
    Nature
    Volume: 577, P: 266-270

  • Acute myeloid leukaemia (AML) affects people of all ages. Here, the authors model AML in vivo and demonstrate that the age of the cell of origin impacts leukaemia development and the genetic signature where adult cells of origin give rise exclusively to AML and young cells of origin give rise to myeloid, lymphoid or mixed phenotype acute leukaemia.

    • Shahzya Chaudhury
    • Caitríona O’Connor
    • Karen Keeshan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14