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Showing 1–4 of 4 results
Advanced filters: Author: Jaron A. M. Mercer Clear advanced filters

  • Current proteolysis-targeting chimeras can promote the ubiquitination and subsequent degradation of both target and off-target proteins by inducing their respective proximity with the cereblon ubiquitin ligase. Now, by developing and deploying an off-target profiling platform, ‘bumped proteolysis-targeting chimeras’ can maintain on-target degradation efficacy with reduced off-targets.

    • Tuan M. Nguyen
    • Vedagopuram Sreekanth
    • Amit Choudhary
    Research
    Nature Chemistry
    Volume: 16, P: 218-228

  • A concise synthesis of the fungal natural product epicolactone suggests that this highly stereochemically complex yet racemic natural product may come from a cascade reaction between two polyhydroxylated arenes.

    • Jaron A. M. Mercer
    • Noah Z. Burns
    News & Views
    Nature Chemistry
    Volume: 7, P: 860-861

  • The mechanochemical activation of [4]-ladderane/ene has been studied and found to exhibit cascade unzipping and a consistent stereochemical distribution of products under various conditions and in different polymer backbones. Ab initio steered molecular dynamics simulations revealed unique non-equilibrium dynamic effects in the mechanochemistry of ladderane, cascade activation and reaction pathway bifurcation.

    • Zhixing Chen
    • Xiaolei Zhu
    • Yan Xia
    Research
    Nature Chemistry
    Volume: 12, P: 302-309