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Showing 1–5 of 5 results
Advanced filters: Author: Jarrett R. Remsberg Clear advanced filters

  • HDAC3 is a critical mediator of hepatic lipid metabolism and its loss leads to fatty liver. Here, the authors characterize the liver HDAC3 interactome in vivo, provide evidence that HDAC3 interacts with PROX1, and show that HDAC3 and PROX1 control expression of genes regulating lipid homeostasis.

    • Sean M. Armour
    • Jarrett R. Remsberg
    • Mitchell A. Lazar
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Integrated phenotypic screening and activity-based protein profiling identifies small molecules that decrease the expression of oncogenic transcription factors and suppress cancer cell growth by covalently targeting the RNA-binding protein NONO.

    • Stefan G. Kathman
    • Seong Joo Koo
    • Benjamin F. Cravatt
    Research
    Nature Chemical Biology
    Volume: 19, P: 825-836

  • A set of enantioprobes—photoreactive, clickable fragment pairs differing only in absolute stereochemistry—have been used to provide a robust and streamlined chemical proteomic map of small-molecule/protein interactions in human cells. More than 170 stereoselective fragment–protein interactions were discovered and shown to occur at functional sites on proteins from diverse classes.

    • Yujia Wang
    • Melissa M. Dix
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 11, P: 1113-1123

  • Determining which covalent binding events impact protein function is challenging. Now, a strategy has been reported that integrates base editing and chemical proteomics to infer the functionality of ligandable cysteines in cancer dependency proteins by quantifying the impact of their missense mutation on cancer cell proliferation.

    • Haoxin Li
    • Tiantai Ma
    • Benjamin F. Cravatt
    Research
    Nature Chemical Biology
    Volume: 19, P: 1320-1330