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Showing 1–3 of 3 results
Advanced filters: Author: Jasmin Hafner Clear advanced filters
  • The top down cheminformatics method is usually used for the reconstitution of heterologous pathway to produce plant natural products. Here, the authors report a bottom up computational workflow for the identification of potential products and the enzymes required to make them in a noscapine pathway in yeast.

    • Jasmin Hafner
    • James Payne
    • Christina Smolke
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14
  • “Mapping the dark matter of metabolism remains an open challenge that can be addressed globally and systematically by existing computational solutions. Here the authors present ATLASx, a repository of known and predicted enzymatic reaction, connecting millions of compounds to help synthetic biologists and metabolic engineers to design and explore metabolic pathways.”

    • Homa MohammadiPeyhani
    • Jasmin Hafner
    • Vassily Hatzimanikatis
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • An integrated structural biology approach uncovers the structural complexity of the intrinsically disordered region (IDR) within the TRPV4 ion channel. Multiple stimulatory and inhibitory elements were identified within the IDR that modulate channel activity in a lipid-dependent manner.

    • Benedikt Goretzki
    • Christoph Wiedemann
    • Ute A. Hellmich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20