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Showing 1–4 of 4 results
Advanced filters: Author: Jason D Doles Clear advanced filters

  • Altered stem cell homeostasis underlies functional tissue decline during muscle aging and disease progression. Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.

    • Jason D Doles
    • Bradley B Olwin
    News & Views
    Nature Medicine
    Volume: 20, P: 1094-1095

  • In two new studies, Helen Blau and Bradley Olwin and their colleagues show that muscle stem cells in aged mice have an intrinsic defect in their stem cell capacity, contributing to age-related sarcopenia. They also provide mechanistic insight to explain this phenomenon and show that biochemical and biophysical manipulations can overcome the defect, suggesting a possible future route of therapy.

    • Jennifer D Bernet
    • Jason D Doles
    • Bradley B Olwin
    Research
    Nature Medicine
    Volume: 20, P: 265-271