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Showing 1–10 of 10 results
Advanced filters: Author: Jason Devoss Clear advanced filters

  • Single-nucleotide polymorphisms (SNPs) in TASL are associated with an increased risk for systemic lupus erythematosus (SLE), but how these SNPs and TASL contribute to disease is unclear. Here the authors demonstrate that Tasl is required for disease pathogenesis in pre-clinical mouse models of SLE, and that an SLE-associated SNP in TASL increases its protein translation.

    • Laura Lau
    • Taryn A. Cariaga
    • Paolo S. Manzanillo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK with a similar efficacy to BAFF inhibition in two mouse models of SLE.

    • Hans D. Brightbill
    • Eric Suto
    • Nico Ghilardi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of conventional versus autoreactive T-cell responses.

    • Eugene Y. Chiang
    • Tianbo Li
    • Jane L. Grogan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Type 2 innate lymphoid cells (ILC2 cells) provide early immune responses to helminthes and contribute to allergic inflammation. Singh and colleagues show that the transcription factor Gfi1 controls the development, activation and specification of ILC2 cells.

    • Chauncey J Spooner
    • Justin Lesch
    • Harinder Singh
    Research
    Nature Immunology
    Volume: 14, P: 1229-1236

  • The Crohn’s disease risk-conferring T300A variant in the autophagy protein ATG16L1 increases its sensitivity to caspase-3-mediated cleavage; this decreases the induction of autophagy in response to metabolic stress or pathogen infection, leading to increased secretion of inflammatory cytokines.

    • Aditya Murthy
    • Yun Li
    • Menno van Lookeren Campagne
    Research
    Nature
    Volume: 506, P: 456-462

  • The deubiquitinase enzyme DUBA is shown to act as a negative regulator of interleukin-17A (IL-17A) in TH17 cells; DUBA interacts with and stabilizes the ubiquitin ligase UBR5, which in turn targets RORγt for degradation in the proteaseome, thus limiting IL-17A production.

    • Sascha Rutz
    • Nobuhiko Kayagaki
    • Vishva M. Dixit
    Research
    Nature
    Volume: 518, P: 417-421