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Showing 1–6 of 6 results
Advanced filters: Author: Jason M. Sheltzer Clear advanced filters

  • In the United States, Black patients have higher rates of cancer mortality, but the sources of such disparities remain poorly understood. Here, the authors analyze genomic data from large-scale patient cohorts and find that cancers from self-reported Black patients are significantly more likely to exhibit whole genome duplications; they also explore a potential link to environmental exposures.

    • Leanne M. Brown
    • Ryan A. Hagenson
    • Jason M. Sheltzer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The development of successful anticancer therapies relies on identifying drug targets that are genuine cancer-specific vulnerabilities. In this article, Lin and Sheltzer discuss how the different genetic and pharmacological methods for identifying and characterizing cancer dependencies each have important strengths and limitations. Responsible and orthogonal use of these methods holds promise for maximizing the ability of preclinical research to translate into clinical benefit.

    • Ann Lin
    • Jason M. Sheltzer
    Reviews
    Nature Reviews Genetics
    Volume: 21, P: 671-682

  • Understanding the timing and fitness of somatic copy number alterations (SCNAs) in cancer would shed light on cancer progression and evolution. Here, the authors develop Butte, a computational framework to estimate the timing of clonal SCNAs that encompass multiple gains, and apply it on whole-genome sequencing data from 184 samples.

    • Zicheng Wang
    • Yunong Xia
    • Ruping Sun
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Independent fellowships provide an opportunity for junior scientists to found their own lab directly after completing their PhD. However, these positions show a striking gender bias that has remained consistent for almost 30 years.

    • Jason M Sheltzer
    Comments & Opinion
    Nature Biotechnology
    Volume: 36, P: 1018-1021

  • This Review discusses the diverse facets of cancer biology that are shaped by aneuploidy and highlights the distinct roles of aneuploidy as both a tumour promoter and an anticancer vulnerability.

    • Anand Vasudevan
    • Klaske M. Schukken
    • Jason M. Sheltzer
    Reviews
    Nature Reviews Cancer
    Volume: 21, P: 89-103