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Showing 1–10 of 10 results
Advanced filters: Author: Jason R. Gerstner Clear advanced filters

  • Circadian cycling of biological processes is widely conserved across phylogeny. Gerstner and Yin discuss how regulators of circadian rhythms — including clock genes, melatonin and the suprachiasmatic nucleus — affect synaptic plasticity and memory formation.

    • Jason R. Gerstner
    • Jerry C. P. Yin
    Reviews
    Nature Reviews Neuroscience
    Volume: 11, P: 577-588

  • A survey of SARS-CoV-2 RBD antibodies identifies those with activity against diverse SARS-CoV-2 variants and SARS-related coronaviruses, highlighting epitopes and features to prioritize in antibody and vaccine development.

    • Tyler N. Starr
    • Nadine Czudnochowski
    • Gyorgy Snell
    Research
    Nature
    Volume: 597, P: 97-102

  • The authors provide preclinical testing of a CSFR-1 inhibitor in proneural glioma models. The compound targets macrophages in the tumor microenvironment rather than tumor cells themselves and is shown to portend considerable antitumor effects. Its activity relies on re-education of tumor-associated macrophages without affecting their survival, reverting their tumor-promoting phenotype. Moreover, gene signatures capturing the tumorigenic features of macrophages can predict survival in human patients with glioma, underscoring the potential relevance of this strategy as a glioma therapy.

    • Stephanie M Pyonteck
    • Leila Akkari
    • Johanna A Joyce
    Research
    Nature Medicine
    Volume: 19, P: 1264-1272

  • Timothy Chan and colleagues report exome and genome sequencing of 60 adenoid cystic carcinoma (ACC) tumor-normal pairs. They identify multiple pathways recurrently disrupted in ACC and provide evidence that KDM6A and PIK3CA are functionally relevant candidate ACC driver genes.

    • Allen S Ho
    • Kasthuri Kannan
    • Timothy A Chan
    Research
    Nature Genetics
    Volume: 45, P: 791-798

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186