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Showing 1–7 of 7 results
Advanced filters: Author: Jason R. Stagno Clear advanced filters

  • Nucleic acid superstructures are required to package genomes into the nucleus of cells. In this study, the superstructure of an RNA supercoil species is reported and is shown to be dependent on an RNA-binding protein that induces a higher level of organization compared with DNA superstructures.

    • Jason R. Stagno
    • Buyong Ma
    • Xinhua Ji
    Research
    Nature Communications
    Volume: 3, P: 1-5

  • HORNET, a method that uses unsupervised machine learning and deep neural networks to analyse atomic force microscopy data enables structural determination of RNA molecules in multiple conformations.

    • Maximilia F. S. Degenhardt
    • Hermann F. Degenhardt
    • Yun-Xing Wang
    ResearchOpen Access
    Nature
    Volume: 637, P: 1234-1243

  • Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.

    • Yun-Tzai Lee
    • Maximilia F. S. Degenhardt
    • Yun-Xing Wang
    ResearchOpen Access
    Nature
    Volume: 637, P: 1244-1251

  • Time-resolved crystallography (TRX) is used for monitoring only small conformational changes of biomacromolecules within the same lattice. Here, the authors report the interplay between synchronous molecular rearrangements and lattice phase transitions in RNA crystals, providing the basis for the investigation of large conformational changes using TRX.

    • Saminathan Ramakrishnan
    • Jason R. Stagno
    • Yun-Xing Wang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • RNA conformational heterogeneity is important to diverse functions. Here, the authors use AFM to directly visualize individual RNA molecules that are in various conformational states under near physiological solution conditions for the first time.

    • Jienyu Ding
    • Yun-Tzai Lee
    • Yun-Xing Wang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11