Nature Search

Erratum: Integrins in cancer: biological implications and therapeutic opportunities

Jay S. Desgrosellier
David A. Cheresh
Amendments and Corrections24 Nov 2010
Nature Reviews Cancer

Volume: 10, P: 890
An integrin α_vβ₃–c-Src oncogenic unit promotes anchorage-independence and tumor progression

Jay S Desgrosellier
Leo A Barnes
David A Cheresh
Research06 Sept 2009
Nature Medicine

Volume: 15, P: 1163-1169
An integrin β₃–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

Cheresh and colleagues delineate a pathway that regulates tumour cell stemness and resistance to therapy. They find that the unliganded integrin α_vβ₃ is able to promote cancer cell self-renewal, tumour initiation and resistance to EGFR inhibitors by binding KRAS and RalB to activate the NF-κB pathway.

Laetitia Seguin
Shumei Kato
David A. Cheresh
Research20 Apr 2014
Nature Cell Biology

Volume: 16, P: 457-468
Integrins in cancer: biological implications and therapeutic opportunities

The integrins regulate a diverse array of cellular functions that are crucial to the initiation, progression and metastasis of solid tumours. This Review discusses the exciting developments in targeting integrins, including the recent initiation of a Phase III trial for an integrin antagonist in patients with glioblastoma.

Jay S. Desgrosellier
David A. Cheresh
Reviews01 Jan 2010
Nature Reviews Cancer

Volume: 10, P: 9-22
S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers

Samson Mugisha
Shahnawaz A. Baba
Jay S. Desgrosellier
ResearchOpen Access25 Jan 2025
Oncogene

Volume: 44, P: 1051-1062
Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1

Qi Sun
Yufen Wang
Jay S. Desgrosellier
ResearchOpen Access13 Jan 2022
npj Breast Cancer

Volume: 8, P: 1-10

Quick links

Search

Filter By:

Erratum: Integrins in cancer: biological implications and therapeutic opportunities

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

Integrins in cancer: biological implications and therapeutic opportunities

S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers

Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1

Search

Quick links

An integrin α_vβ₃–c-Src oncogenic unit promotes anchorage-independence and tumor progression

An integrin β₃–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition