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Showing 1–3 of 3 results
Advanced filters: Author: Jayan Rammohan Clear advanced filters
  • Rammohan et al. propose a generalizable framework for performing multiple methods in parallel using split samples, so that experimental variability is defined and compared between methods. Their framework provides a practical solution for benchmarking and comparing the performance of any method, illustrated by analysing single-cell and single-transcript methods.

    • Jayan Rammohan
    • Steven P. Lund
    • David Ross
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14
  • A quantitative assessment of promoter function can improve the precision of cellular engineering. Here the authors develop a method to simultaneously count plasmid DNA, RNA transcripts and protein expression in single living bacteria.

    • Bin Shao
    • Jayan Rammohan
    • Christopher A. Voigt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9
  • 20(S)-hydroxycholesterol binds to Smo at a site distinct from cyclopamine and activates signaling via an allosteric mechanism. A new alkyne oxysterol analog selectively captures Smo from membrane extracts and provides a new method for detecting protein-sterol interactions.

    • Sigrid Nachtergaele
    • Laurel K Mydock
    • Rajat Rohatgi
    Research
    Nature Chemical Biology
    Volume: 8, P: 211-220