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Showing 1–2 of 2 results
Advanced filters: Author: Jayanthi Manne Clear advanced filters

  • Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinase, phosphatidylinositol 3-kinase and RAS pathway genes but find that these mutations were often present in minor subclones and lost at the time of relapse.

    • Anna K Andersson
    • Jing Ma
    • James R Downing
    Research
    Nature Genetics
    Volume: 47, P: 330-337

  • Pediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here the authors analyse the genomes, exomes and transcriptomes of 37 such tumours and identify genetic alterations whose nature, timing and potential interactions are key events with prognostic significance in pediatric adrenocortical tumorigenesis.

    • Emilia M. Pinto
    • Xiang Chen
    • Gerard P. Zambetti
    Research
    Nature Communications
    Volume: 6, P: 1-10