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Showing 1–14 of 14 results
Advanced filters: Author: Jayaraj Rajagopal Clear advanced filters

  • Using in vivo lineage tracing in mice and sorted cells in culture, the ability of stably committed cells to dedifferentiate into basal stem cells in the mouse trachea is investigated: the findings suggest that the dedifferentiation of committed cell types into stem cells may contribute generally to regeneration in higher vertebrates in different organ and injury contexts.

    • Purushothama Rao Tata
    • Hongmei Mou
    • Jayaraj Rajagopal
    Research
    Nature
    Volume: 503, P: 218-223

  • Little is known about how the relative proportions of stem cells and differentiated cells are regulated; basal stem/progenitor cells of the mouse airway epithelium self renew and differentiate into secretory and ciliated cells, and basal stem cells continuously send daughter cells a forward niche signal necessary for daughter cell fate maintenance.

    • Ana Pardo-Saganta
    • Purushothama Rao Tata
    • Jayaraj Rajagopal
    Research
    Nature
    Volume: 523, P: 597-601

  • Human airway contains physiologically relevant yet rare cells, but their scarcity prevents thorough profiling and differentiation studies. Here the authors use single cell RNA sequencing to identify rare ionocytes and tuft cells, as well as a potential progenitor population with cytokine-guided differentiation into either the ionocytes or tuft cell lineage.

    • Viral S. Shah
    • Avinash Waghray
    • Alexander M. Tsankov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Single-cell RNA sequencing analysis identifies cell types and lineages in airway epithelium, including the pulmonary ionocyte, a new cell type predominantly expressing the cystic fibrosis gene CFTR.

    • Daniel T. Montoro
    • Adam L. Haber
    • Jayaraj Rajagopal
    Research
    Nature
    Volume: 560, P: 319-324

  • This paper shows that exocrine cells of the pancreas can be converted in vivo to insulin-secreting endocrine cells. Interestingly, the transdifferentiating cells did not have to revert to a more primitive, pluripotent state in this process, but seemed to move directly from one differentiated state to another.

    • Qiao Zhou
    • Juliana Brown
    • Douglas A. Melton
    Research
    Nature
    Volume: 455, P: 627-632

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577

  • Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.

    • Linh T. Bui
    • Nichelle I. Winters
    • Laure Emmanuelle Zaragosi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13