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Showing 1–3 of 3 results
Advanced filters: Author: Jayasudhan R. Yerabolu Clear advanced filters

  • The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern TCA cycle, shedding light into a plausible TCA protometabolism.

    • Greg Springsteen
    • Jayasudhan Reddy Yerabolu
    • Ramanarayanan Krishnamurthy
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8

  • It’s unclear how protometabolic reactions emerged and evolved into extant metabolic pathways such as the tricarboxylic acid cycle. Now, it has been shown that cyanide acts as a mild and efficient reducing agent, mediating abiotic transformations of tricarboxylic acid intermediates and derivatives.

    • Mahipal Yadav
    • Sunil Pulletikurti
    • Ramanarayanan Krishnamurthy
    Research
    Nature Chemistry
    Volume: 14, P: 170-178

  • Crystal structures of the MEK kinase bound to the scaffold protein KSR and various MEK inhibitors, including the anti-cancer drug trametinib, reveal the molecular and functional mechanisms behind MEK inhibition.

    • Zaigham M. Khan
    • Alexander M. Real
    • Arvin C. Dar
    Research
    Nature
    Volume: 588, P: 509-514