Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Jayme L. Dahlin Clear advanced filters
  • Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with compound-dependent cellular injury and nuisance activity.

    • Jayme L. Dahlin
    • Bruce K. Hua
    • Bridget K. Wagner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are nonselective interference compounds.

    • Jayme L. Dahlin
    • Kathryn M. Nelson
    • Michael A. Walters
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14
  • The recent growth in the number of academic drug discovery centres is providing new opportunities to couple the curiosity-driven research culture in academia with rigorous preclinical drug discovery practices used in industry. To realize the potential of these opportunities, it is important that academic researchers understand the risks in several key areas — including organization, target selection, assay design, medicinal chemistry and preclinical pharmacology — which are discussed in this article.

    • Jayme L. Dahlin
    • James Inglese
    • Michael A. Walters
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 279-294
  • Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

    • Cheryl H Arrowsmith
    • James E Audia
    • William J Zuercher
    Comments & Opinion
    Nature Chemical Biology
    Volume: 11, P: 536-541