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Advanced filters: Author: Jea-woo Kim Clear advanced filters
  • AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.

    • Min-Sik Lee
    • Hyun-Ji Han
    • Jaewhan Song
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14